Can skin exposure to sunlight prevent liver inflammation?
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Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure to sunlight-derived ultraviolet radiation (UVR), the skin releases anti-inflammatory mediators such as vitamin D and nitric oxide. Animal modeling studies suggest that exposure to UVR can prevent the development of NAFLD. Association studies also support a negative link between circulating 25-hydroxyvitamin D and NAFLD incidence or severity. Clinical trials are in their infancy and are yet to demonstrate a clear beneficial effect of vitamin D supplementation. There are a number of potentially interdependent mechanisms whereby vitamin D could dampen liver inflammation, by inhibiting hepatocyte apoptosis and liver fibrosis, modulating the gut microbiome and through altered production and transport of bile acids. While there has been a focus on vitamin D, other mediators induced by sun exposure, such as nitric oxide may also play important roles in curtailing liver inflammation.
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Gorman, S.; Black, Lucinda; Feelisch, M.; Hart, P.; Weller, R. (2015)Liver inflammation contributes towards the pathology of non-alcoholic fatty liver disease (NAFLD). Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. Following exposure ...
Low serum 25-hydroxyvitamin D concentrations are associated with non-alcoholic fatty liver disease in adolescents independent of adiposityBlack, L.; Jacoby, P.; Ping-Delfos, Wendy; Mori, T.; Beilin, L.; Olynyk, John; Ayonrinde, O.; Huang, R.; Holt, P.; Hart, P.; Oddy, W.; Adams, L. (2014)Background and Aims: Non-alcoholic fatty liver disease (NAFLD) and serum 25-hydroxyvitamin D (s25[OH]D) concentrations are both associated with adiposity and insulin resistance (IR) and thus may be pathogenically linked. ...
Serum marker of inflammasome activity correlates with liver injury in nonalcoholic fatty liver disease and is influenced by genetic polymorphismsAdams, L.; Wree, A.; Melton, P.; Jeffrey, G.; Ching, H.; de Boer, B.; Olynyk, J.; Ayonrinde, O.; Mori, T.; Beilin, L.; Price, Patricia; Pennell, C.; Eslam, M.; George, J.; Feldstein, A. (2015)Background and Aims: The NLRP3 inflammasome has been implicated in the pathogenesis of liver injury in nonalcoholic fatty liver disease (NAFLD). In humans, mutations of Nlrp3 have functional consequences and result in ...