Emerging trends in cell and gene therapy
MetadataShow full item record
© 2013 Springer Science+Business Media New York. All rights reserved. Examples from various organs and diseases illustrate the potential benefit obtained when both therapeutic approaches are combined with delivery strategies. Representing the combined effort of several leading international research and clinical experts, this book, Emerging Trends in Cell and Gene Therapy, provides a complete account on and brings into sharp focus current trends and state-of-the-art in important areas at the interface of cell- and gene-based therapies. This book addresses the current fragmented understanding regarding these two research areas and fills the vast unmet educational need and interest of both students and researchers in academia and industry. Main features of the book: Biological aspects of stem cell sources, differentiation and engineering. Application of microfluidics to study stem cell dynamics Potential clinical application of stem cells and gene therapy to specific human disease. Utilization of biomaterials and stem cells in regenerative medicine with particular emphasis on spinal cord repair, ligament and bone tissue engineering. Biomimetic multiscale topography for cell alignment.
Showing items related by title, author, creator and subject.
An integrated genomic approach identifies that the PI3K/AKT/FOXO pathway is involved in breast cancer tumor initiationSmit, L.; Berns, K.; Spence, K.; Ryder, W.; Zeps, Nikolajs; Madiredjo, M.; Beijersbergen, R.; Bernards, R.; Clarke, R. (2015)Therapy resistance is one of the major impediments to successful cancer treatment. In breast cancer, a small subpopulation of cells with stem cell features, named breast cancer stem cells (BCSC), is responsible for ...
Breast cancer stem-like cells are inhibited by diosgenin, a steroidal saponin, by the attenuation of the Wnt ß-catenin signaling via the Wnt antagonist secreted frizzled related protein-4Bhuvanalakshmi, G.; Basappa; Rangappa, K.; Dharmarajan, Arunasalam; Sethi, G.; Kumar, Alan Prem; Warrier, Sudha (2017)© 2017 Bhuvanalakshmi, Basappa, Rangappa, Dharmarajan, Sethi, Kumar and Warrier.Background: Identification of breast cancer stem cells as the chemo-resistant and tumor-initiating population represents an important milestone ...
Mesenchymal stem cell-conditioned media ameliorate diabetic endothelial dysfunction by improving mitochondrial bioenergetics via the Sirt1/AMPK/PGC-1α pathway.Yuan, Y.; Shi, M.; Li, L.; Liu, J.; Chen, B.; Chen, Y.; An, X.; Liu, S.; Luo, R.; Long, D.; Zhang, W.; Newsholme, Philip; Cheng, J.; Lu, Y. (2016)Vasculopathy is a major complication of diabetes. Impaired mitochondrial bioenergetics and biogenesis due to oxidative stress are a critical causal factor for diabetic endothelial dysfunction. Sirt1, an NAD(+)-dependent ...