Comparative Evaluation of AmpliVue HSV 1+2 Assay with ELVIS Culture for Detecting Herpes Simplex Virus 1 (HSV-1) and HSV-2 in Clinical Specimens
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The AmpliVue HSV 1+2 assay was compared to the ELVIS HSV ID and D3 Typing Culture System for the qualitative detection and differentiation of herpes simplex virus 1 (HSV-1) and HSV-2 DNA in 1,351 cutaneous and mucocutaneous specimens. Compared to ELVIS, AmpliVue had sensitivities of 95.7 and 97.6% for detecting HSV-1 and HSV-2, respectively. Following arbitration of discordant results by an independent molecular method, the AmpliVue assay had a resolved sensitivity and specificity of 99.2 and 99.7%, respectively, for both HSV-1 and HSV-2, whereas ELVIS had a resolved sensitivity of 87.1% for HSV-1 and 84.5% for HSV-2.
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Risaliti, G.; Miniutti, G.; Elvis, M.; Fabbiano, G.; Salvati, M.; Baldi, A.; Braito, V.; Bianchi, S.; Matt, G.; Reeves, J.; Soria, Roberto; Zezas, A. (2009)
Risaliti, G.; Salvati, M.; Elvis, M.; Fabbiano, G.; Baldi, A.; Bianchi, S.; Braito, V.; Guainazzi, M.; Matt, G.; Miniutti, G.; Reeves, J.; Soria, Roberto; Zezas, A. (2009)
Soria, Roberto; Risaliti, G.; Elvis, M.; Fabbiano, G.; Bianchi, S.; Kuncic, Z. (2009)