BAX/BCL2 RMFI ratio predicts better induction response in pediatric patients with acute myeloid leukemia
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BAX/BCL2 ratio in pediatric AML has not been evaluated. In this first prospective study, we evaluated BAX/BCL2 transcript and RMFI ratio in 64 patients using real-time PCR (TaqMan Probe chemistry) and flow-cytometry, respectively. There was no correlation of BAX/BCL2 transcript ratio with RMFI ratio (R=-0.05; P=0.715). Patients with WBC count >50,000/mm3 had lower BAX/BCL2 RMFI ratio (P=0.043), whereas no difference in ratio was observed among patients of different cytogenetics subgroups (P=0.786). Higher BAX/BCL2 RMFI ratio was associated positively with CR rate (P=0.03), but this study was unable to show that it translated into improved EFS or OS. © 2013 Wiley Periodicals, Inc.
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