Significantly reduced regulatory T cell population in patients with untreated multiple myeloma
MetadataShow full item record
Increases in regulatory T-cells have been demonstrated in hematological malignancies but conflicting results have been reported in multiple myeloma (MM). In this study, we report a decrease in frequency of regulatory T-cells as well as reduced expression of FoxP3 in untreated MM patients which increased significantly after treatment. Regulatory T-cells of MM patients exhibited immunosuppressive activity in an in vitro assay. Reduced regulatory T-cells in untreated MM patients which increased after treatment with thalidomide, suggests the analysis of treated and untreated patients as a single cohort as cause of conflicting results in earlier studies on regulatory T-cells in MM. © 2010 Elsevier Ltd.
Showing items related by title, author, creator and subject.
CD31 (PECAM-1) is a marker of recent thymic emigrants among CD4+ T-cells, but not CD8+ T-cells or ? d T-cells, in HIV patients responding to ARTTanaskovic, S.; Fernandez, S.; Price, Patricia; Lee, S.; French, M. (2010)Some severely immunodeficient HIV patients experience poor recovery of CD4 T-cell counts on antiretroviral therapy (ART). Evaluation of the function of thymopoiesis in T-cell production in individual patients requires a ...
Immunological profiles of immune restoration disease presenting as mycobacterial lymphadenitis and cryptococcal meningitisTan, D.; Yong, Y.; Tan, H.; Kamarulzaman, A.; Tan, L.; Lim, A.; James, I.; French, M.; Price, Patricia (2008)Objectives: A proportion of HIV patients beginning antiretroviral therapy (ART) develop immune restoration disease (IRD). Immunological characteristics of IRD were investigated in a cohort of HIV patients beginning therapy ...
Impaired function of regulatory T-cells in patients with chronic obstructive pulmonary disease (COPD)Tan, D.; Fernandez, S.; Price, Patricia; French, M.; Thompson, P.; Moodley, Y. (2014)Anti-inflammatory pathways affecting chronic obstructive pulmonary disease (COPD) are poorly understood. Regulatory T-cells (Tregs) are important negative regulators of T-cell activity and hence were investigated in COPD ...