Role of extracellular matrix in muscle repair and regeneration
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Extracellular matrices (ECMs) play important structural and mechanical roles in muscle tissue. They are also critical for normal muscle homeostasis, but it is poorly understood how individual matrix proteins, or the mix of ECM proteins found in vivo affect myoblast behaviour. Aspects of this question have been examined in this thesis using both matrices from skeletal muscle and artificial scaffolds prepared from silk proteins. The ability of these surfaces to support myoblast proliferation and differentiation was examined using a murine myoblast cell line and primary human skeletal muscle myoblasts.
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Interactions between skeletal muscle myoblasts and their extracellular matrix revealed by a serum free culture systemChaturvedi, Vishal; Dye, Danielle; Kinnear, Bev; Van Kuppevelt, T.; Grounds, M.; Coombe, Deidre (2015)Decellularisation of skeletal muscle provides a system to study the interactions of myoblasts with muscle extracellular matrix (ECM). This study describes the efficient decellularisation of quadriceps muscle with the ...
Chaturvedi, Vishal (2014)Extracellular matrices (ECMs) play important structural and mechanical roles in muscle tissue. They are also critical for normal muscle homeostasis, but it is poorly understood how individual matrix proteins, or the mix ...
Silk fibroin scaffolds with muscle-like elasticity support in vitro differentiation of human skeletal muscle cellsChaturvedi, V.; Naskar, D.; Kinnear, B.; Grenik, E.; Dye, Danielle; Grounds, M.; Kundu, S.; Coombe, D. (2016)Human adult skeletal muscle has a limited ability to regenerate after injury and therapeutic options for volumetric muscle loss are few. Technologies to enhance regeneration of tissues generally rely upon bioscaffolds to ...