Thymic tissue is not evident on high-resolution computed tomography and 2-[18F]-fluoro-2-deoxy-D-glucose positron emission tomography scans of viraemic HIV patients with poor recovery of CD4+ T cells
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Some previously immunodeficient HIV patients responding to antiretroviral therapy display poor recovery of CD4 T cells. Evaluation of the contribution of thymic function requires sensitive detection and quantitation of metabolically active thymic tissue. We describe patients with low but detectable thymopoiesis assessed as circulating CD4 naive T cells expressing CD31. High-resolution computed tomography and PET scans found no residual thymic tissue even though metabolic activity was demonstrable by PET in lymph nodes.