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dc.contributor.authorMunro, A.
dc.contributor.authorWilliams, V.
dc.contributor.authorSemmens, J.
dc.contributor.authorLeung, Y.
dc.contributor.authorStewart, C.
dc.contributor.authorCodde, J.
dc.contributor.authorSpilsbury, K.
dc.contributor.authorSteel, N.
dc.contributor.authorCohen, P.
dc.contributor.authorO'Leary, Peter
dc.date.accessioned2018-01-30T07:59:44Z
dc.date.available2018-01-30T07:59:44Z
dc.date.created2018-01-30T05:59:09Z
dc.date.issued2015
dc.date.submitted2018-01-30
dc.identifier.citationMunro, A. and Williams, V. and Semmens, J. and Leung, Y. and Stewart, C. and Codde, J. and Spilsbury, K. et al. 2015. Risk of high-grade cervical dysplasia and gynaecological malignancies following the cytologic diagnosis of atypical endocervical cells of undetermined significance: A retrospective study of a state-wide screening population in Western Australia. The Australian and New Zealand Journal of Obstetrics and Gynaecology. 55 (3): pp. 268-273.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/60293
dc.identifier.doi10.1111/ajo.12336
dc.description.abstract

Background: In 2006, Australia adopted a revised cervical cytology terminology system, known as the Australian Modified Bethesda System (AMBS). One substantial change in the AMBS was the introduction of the diagnostic category of atypical endocervical cells (AEC) of undetermined significance. Aim: The aim of this study was to investigate the incidence of histologically confirmed high-grade cervical dysplasia (cervical intra-epithelial neoplasia (CIN) grades 2 and 3 and adenocarcinoma in situ (ACIS)), cervical carcinoma and endometrial carcinoma in women presenting with AEC on cervical cytology. Methods: A seven-year retrospective study examining clinical outcomes of women with AEC on a screening cervical smear. Cytology and histology results were extracted from the Western Australia Cervical Screening Registry, and time-toevent analysis was used to predict the odds of having or developing in situ and invasive neoplasia. Results: AEC was reported in index smears from 0.093% (584/622754) women during the study period. No follow-up was available in 35 AEC cases. Sixty-five of the remaining 549 women (11.8%) had, or developed, high-grade cervical dysplasia within five years of their index AEC diagnosis. Endometrial cancer was diagnosed in 21 women and cervical cancer in four women during the follow-up period. Conclusion: Cytologic demonstration of AEC requires careful gynaecologic evaluation, particularly in younger women who may be found to have either high-grade squamous (CIN) or glandular (ACIS) lesions, while in older women, the possibility of endometrial neoplasia needs to be considered.

dc.publisherBlackwell Publishing
dc.titleRisk of high-grade cervical dysplasia and gynaecological malignancies following the cytologic diagnosis of atypical endocervical cells of undetermined significance: A retrospective study of a state-wide screening population in Western Australia
dc.typeJournal Article
dcterms.dateSubmitted2018-01-30
dcterms.source.volume55
dcterms.source.number3
dcterms.source.startPage268
dcterms.source.endPage273
dcterms.source.issn0004-8666
dcterms.source.titleThe Australian and New Zealand Journal of Obstetrics and Gynaecology
curtin.digitool.pid259231
curtin.departmentHealth Sciences Research and Graduate Studies
curtin.identifier.elementsidELEMENTS-95076
curtin.accessStatusOpen access via publisher


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