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    Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions

    Access Status
    Open access via publisher
    Authors
    Deen, J.
    Ali, Mohammed
    Sack, D.
    Date
    2014
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
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    Abstract

    There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine. © 2014 Deen et al.

    Citation
    Deen, J. and Ali, M. and Sack, D. 2014. Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions. PLoS ONE. 9 (2).
    Source Title
    PLoS ONE
    URI
    http://hdl.handle.net/20.500.11937/65698
    DOI
    10.1371/journal.pone.0088139
    Department
    School of Nursing, Midwifery and Paramedicine

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