Methods to assess the impact of mass oral cholera vaccination campaigns under real field conditions
Access Status
Authors
Date
2014Collection
Type
Metadata
Show full item recordAbstract
There is increasing interest to use oral cholera vaccination as an additional strategy to water and sanitation interventions against endemic and epidemic cholera. There are two internationally-available and WHO-prequalified oral cholera vaccines: an inactivated vaccine containing killed whole-cells of V. cholerae O1 with recombinant cholera toxin B-subunit (WC/rBS) and a bivalent inactivated vaccine containing killed whole cells of V. cholerae O1 and V. cholerae O139 (BivWC). The efficacy, effectiveness, direct and indirect (herd) protection conferred by WC/rBS and BivWC are well established. Yet governments may need local evidence of vaccine impact to justify and scale-up mass oral cholera vaccination campaigns. We discuss various approaches to assess oral cholera vaccine protection, which may be useful to policymakers and public health workers considering deployment and evaluation of the vaccine. © 2014 Deen et al.
Citation
Source Title
Department
Related items
Showing items related by title, author, creator and subject.
-
Ali, Mohammed; Nelson, A.; Luquero, F.; Azman, A.; Debes, A.; M'bang'ombe, M.; Seyama, L.; Kachale, E.; Zuze, K.; Malichi, D.; Zulu, F.; Msyamboza, K.; Kabuluzi, S.; Sack, D. (2017)© 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license Background Pregnancy increases the risk of harmful effects from cholera for both mothers and their fetuses. A killed ...
-
Qadri, F.; Wierzba, T.; Ali, Mohammed; Chowdhury, F.; Khan, A.; Saha, A.; Khan, I.; Asaduzzaman, M.; Akter, A.; Khan, A.; Begum, Y.; Bhuiyan, T.; Khanam, F.; Chowdhury, M.; Islam, T.; Chowdhury, A.; Rahman, A.; Siddique, S.; You, Y.; Kim, D.; Siddik, A.; Saha, N.; Kabir, A.; Cravioto, A.; Desai, S.; Singh, A.; Clemens, J. (2016)Copyright © 2016 Massachusetts Medical Society. All rights reserved. Background: A single-dose regimen of the current killed oral cholera vaccines that have been prequalified by the World Health Organization would make ...
-
Khatib, A.; Ali, Mohammed; von Seidlein, L.; Kim, D.; Hashim, R.; Reyburn, R.; Ley, B.; Thriemer, K.; Enwere, G.; Hutubessy, R.; Aguado, M.; Kieny, M.; Lopez, A.; Wierzba, T.; Ali, S.; Saleh, A.; Mukhopadhyay, A.; Clemens, J.; Jiddawi, M.; Deen, J. (2012)Background: Zanzibar, in east Africa, has been severely and repeatedly affected by cholera since 1978. We assessed the effectiveness of oral cholera vaccination in high-risk populations in the archipelago to estimate the ...