Novel benzimidazo[2,1-c][1,4]thiazinone derivatives with potent activity against HSV-1
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The synthesis of new 2-carboxymethylsulfanylmethyl-1H-benzimidazole and 1,3-dihydro-4H-benzo[ 4',5']imidazo[2,1-c] [1,4]thiazine-4-one-8- carboxylic acid derivatives was investigated. The antiviral activity of compounds 1-14 was tested against the herpes simplex virus 1. Compounds 5 and 14 showed potent activity as they inhibited virus propagation by 94.7% and 91.3% at a dose of 50 µg, respectively. Compounds 5 and 14 showed higher potency than Acyclovir at doses of 20 µg and 50 µg. © 2011 Wiley-VCH Verlag GmbH & Co. KGaA.