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    Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)- furanone: Anti-avian influenza virus (H5N1) activity

    Access Status
    Open access via publisher
    Authors
    Flefel, E.
    Abdel-Mageid, R.
    Tantawy, W.
    Ali, Mohammed
    Amr, A.
    Date
    2012
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
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    Abstract

    3-[2-(4-Bromphenyl)hydrazono]-5-phenyl-furan-2(3H)-one (1) was used for preparation of some novel pyrazole, pyridazinone, oxadiazole, triazole, thiazolidine and thioxopyrimidine derivatives. Some of the prepared products were tested for anti-avian influenza virus activity and revealed promising antiviral activity against H5N1 virus [A/Chicken/Egypt/1/20 % (H5N1)] by determination of both EC50 and LD50 and confirmed by plaque reduction assay on Madin-Darby canine kidney cells. Compounds 3-[2-(4-bromophenyl)hydrazono]-5- phenylfuran-2(3H)-one (1), 1-(4-bromophenyl)-N-hydroxy-5-phenyl-1H-pyrazole-3- carboxamide (5) and 1-(4-bromophenyl)-N-{2,3-dihydro-4-hydroxy-3-phenyl-6-oxo-2- thioxopyrimidin-1(6H)-yl}-5-phenyl-1H-pyrazole-3-carboxamide (12a) showed the highest effects. Detailed synthesis, spectroscopic data, and antiviral activity of the synthesized compounds are reported.

    Citation
    Flefel, E. and Abdel-Mageid, R. and Tantawy, W. and Ali, M. and Amr, A. 2012. Heterocyclic compounds based on 3-(4-bromophenyl) azo-5-phenyl-2(3H)- furanone: Anti-avian influenza virus (H5N1) activity. Acta Pharmaceutica. 62 (4): pp. 593-606.
    Source Title
    Acta Pharmaceutica
    URI
    http://hdl.handle.net/20.500.11937/65819
    DOI
    10.2478/v10007-012-0037-7
    Department
    School of Nursing, Midwifery and Paramedicine

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