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    Biological characterization of highly pathogenic avian influenza H5N1 viruses that infected humans in Egypt in 2014-2015

    Access Status
    Fulltext not available
    Authors
    El-Shesheny, R.
    Mostafa, A.
    Kandeil, A.
    Mahmoud, S.
    Bagato, O.
    Naguib, A.
    Refaey, S.
    Webby, R.
    Ali, Mohammed
    Kayali, G.
    Date
    2017
    Collection
    • Curtin Research Publications
    Type
    Journal Article
    Metadata
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    Abstract

    © 2016, Springer-Verlag Wien. Highly pathogenic avian influenza (HPAI) H5N1 influenza viruses emerged as a human pathogen in 1997 with expected potential to undergo sustained human-to-human transmission and pandemic viral spread. HPAI H5N1 is endemic in Egyptian poultry and has caused sporadic human infection. The first outbreak in early 2006 was caused by clade 2.2 viruses that rapidly evolved genetically and antigenically. A sharp increase in the number of human cases was reported in Egypt in the 2014/2015 season. In this study, we analyzed and characterized three isolates of HPAI H5N1 viruses isolated from infected humans in Egypt in 2014/2015. Phylogenetic analysis demonstrated that the nucleotide sequences of eight segments of the three isolates were clustered with those of members of clade 2.2.1.2. We also found that the human isolates from 2014/2015 had a slight, non-significant difference in their affinity for human-like sialic acid receptors. In contrast, they showed significant differences in their replication kinetics in MDCK, MDCK-SIAT, and A549 cells as well as in embryonated chicken eggs. An antiviral bioassay study revealed that all of the isolates were susceptible to amantadine. Therefore, further investigation and monitoring is required to correlate the genetic and/or antigenic changes of the emerging HPAI H5N1 viruses with possible alteration in their characteristics and their potential to become a further threat to public health.

    Citation
    El-Shesheny, R. and Mostafa, A. and Kandeil, A. and Mahmoud, S. and Bagato, O. and Naguib, A. and Refaey, S. et al. 2017. Biological characterization of highly pathogenic avian influenza H5N1 viruses that infected humans in Egypt in 2014-2015. Archives of Virology. 162 (3): pp. 687-700.
    Source Title
    Archives of Virology
    URI
    http://hdl.handle.net/20.500.11937/65841
    DOI
    10.1007/s00705-016-3137-8
    Department
    School of Nursing, Midwifery and Paramedicine

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