A marked shift in innate and adaptive immune response in chinese immigrants living in a western environment
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We have previously reported that in comparison to their counterparts that have recently arrived from China, Chinese immigrants living in Australia for several years displayed attenuated innate cytokine responses following triggering of most TLRs, except for TLR-4.These immigrants also had overall increased methylation and decreased gene expression, which are consistent with recent findings suggesting that allergy-contributing factors such as microbial exposure, diet and environmental agents mediate their influence through alterations of the epigenetic landscape. Delayed maturation of the immune system with decreased production of IFN-? at birth (Th1) and a prolonged postnatal Th2 deviation is associated with the development of allergy in childhood. This article is protected by copyright. All rights reserved.