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dc.contributor.authorBolik, Julia
dc.contributor.authorTirnitz-Parker, Nina
dc.contributor.authorSchmidt-Arras, Dirk
dc.date.accessioned2020-02-14T05:45:24Z
dc.date.available2020-02-14T05:45:24Z
dc.date.issued2019
dc.identifier.citationBolik, J. and Tirnitz-Parker, J. and Schmidt-Arras, D. 2019. ADAM and ADAMTS Proteases in Hepatic Disorders. Journal of Renal and Hepatic Disorders. 3 (1): pp. 23-32.
dc.identifier.urihttp://hdl.handle.net/20.500.11937/77927
dc.identifier.doi10.15586/jrenhep.2019.47
dc.description.abstract

Proteolysis is an irreversible post-translational modification that regulates protein function and signal transduction. This includes remodelling of the extracellular matrix, release of membrane-bound cytokines and receptor ectodomains, as well as the initiation of intracellular signalling cues. Members of the adamalysin protease subfamily, in particular the ADAM (a disintegrin and metalloprotease) and ADAMTS (the ADAM containing thrombospondin motif) families, are involved in these processes. This review presents an overview of how ADAM and ADAMTS proteins are involved in liver physiology and pathophysiology.

dc.publisherCodon Publications
dc.rights.urihttp://creativecommons.org/licenses/by/4.0
dc.titleADAM and ADAMTS Proteases in Hepatic Disorders
dc.typeJournal Article
dcterms.source.volume3
dcterms.source.number1
dcterms.source.startPage23
dcterms.source.endPage32
dcterms.source.issn2207-3744
dcterms.source.titleJournal of Renal and Hepatic Disorders
dc.date.updated2020-02-14T05:45:24Z
curtin.departmentSchool of Pharmacy and Biomedical Sciences
curtin.accessStatusOpen access
curtin.facultyFaculty of Health Sciences
curtin.contributor.orcidTirnitz-Parker, Nina [0000-0002-3558-5892]
curtin.contributor.scopusauthoridTirnitz-Parker, Nina [8406405800]


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