The mode of action of bone morphogenetic protein (bmp) in the regulation of ovarian function
Access Status
Open access
Authors
Regan, Sheena Linnette Patricia
Date
2015Supervisor
Prof. Arunasalam Dharmarajan
Dr Kevin Keane
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School of Biomedical Science
Collection
Abstract
The aim of this thesis was to establish the specific role of bone morphogenetic protein (BMP) in the regulation of ovulation rate, and the effect of ageing on receptor expression. Ovarian follicle depletion was associated with a reduction in receptor expression. Growth hormone co-treatment during IVF reversed some of the ageing effects. The results are significant and central to the development of a new clinical approach to improve human female fertility.