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    The mode of action of bone morphogenetic protein (bmp) in the regulation of ovarian function

    238881_Regan 2016.pdf (13.05Mb)
    Access Status
    Open access
    Authors
    Regan, Sheena Linnette Patricia
    Date
    2015
    Supervisor
    Prof. Arunasalam Dharmarajan
    Dr Kevin Keane
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    School
    School of Biomedical Science
    URI
    http://hdl.handle.net/20.500.11937/1392
    Collection
    • Curtin Theses
    Abstract

    The aim of this thesis was to establish the specific role of bone morphogenetic protein (BMP) in the regulation of ovulation rate, and the effect of ageing on receptor expression. Ovarian follicle depletion was associated with a reduction in receptor expression. Growth hormone co-treatment during IVF reversed some of the ageing effects. The results are significant and central to the development of a new clinical approach to improve human female fertility.

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