The role of the sFRP4 protein in modulation of cancer growth and anti-neoplastic drug sensitivity

Abstract

This project found that reintroducing a regulatory protein, sFRP4, to mesothelioma cancer cell models could inhibit their growth, ability to migrate and induce a form of cell death. In addition sFRP4 could sensitise mesothelioma cells to drug treatment. The mechanisms involved were studied in detail and the project provided new insights into the functions of this protein including identifying the protein structures involved in these effects and its role in cancer cells.