Factors affecting skeletal integrity in an Australia Rett syndrome cohort and best practice guidelines for prevention and management of low bone density in Rett syndrome
Access Status
Open access
Authors
Jefferson, Amanda Louise
Date
2016Supervisor
Prof. Sue Fyfe
Assoc. Prof. Deborah Kerr
Assoc. Prof. Helen Leonard
Dr Jennepher Downs
Type
Thesis
Award
MPhil
Metadata
Show full item recordSchool
School of Public Health
Collection
Abstract
Rett syndrome is a rare genetic neurodevelopmental disorder. Cross sectional and longitudinal densitometry assessment in Rett syndrome found decreased bone density with age but muscle mass and mensus afforded some protection. Consensus-based clinical management guidelines provided recommendations for clinical assessment and pharmacological and non-pharmacological interventions. These data have the potential to reduce the frequency of fractures in Rett syndrome and stimulate further research that aims to ameliorate the impacts of poor bone health.
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