Chemistry of clerodane diterpenes isolated from Dodonaea species in Western Australia

Moussa, Vasoulla Noelle

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Access Status

Open access

Authors

Moussa, Vasoulla Noelle

Date

2015

Supervisor

Assoc. Prof. Mauro Mocerino

Dr Alan Payne

Type

Thesis

Award

PhD

Metadata

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School

Department of Chemistry

URI

http://hdl.handle.net/20.500.11937/1738

Collection

Curtin Theses

Abstract

A new clerodane diterpene was isolated from the leaf resin of Dodonaea ceratocarpa in an appreciable quantity. The inherent chemistry of this new compound was studied to evaluate its potential as a starting material for the pharmaceutical industry. A suite of new clerodanes were synthesised.Cordytropolone is a natural product isolated from Cordyceps that gave moderate inhibition against P. falciparum in vivo. A total synthesis was investigated using a thiophene-1,1-dioxide.