Stabilisation of oxytocin in aqueous injection solutions

Al Zayadi, Ahmad Farhan Khinteel

Access Status

Fulltext not available

Authors

Al Zayadi, Ahmad Farhan Khinteel

Date

2015

Supervisor

Prof. Vivian Sunderland

Dr Victor Chuang

Type

Thesis

Award

PhD

Metadata

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School

School of Pharmacy

Remarks

This thesis is under permanent embargo

URI

http://hdl.handle.net/20.500.11937/1911

Collection

Curtin Theses

Abstract

Oxytocin is important treatment in labour. This study investigated the degradation kinetics of oxytocin as a function of temperature, pH and other parameters and investigated the influence of formulation additives. Also investigated the storage of some of oxytocin injection stored in Vietnam. Oxytocin was most stable at pH 3.5 but highly affected by temperature. Improper storage can lead to premature expiry when the injection is not refrigerated.