Stabilisation of oxytocin in aqueous injection solutions
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Fulltext not available
Authors
Al Zayadi, Ahmad Farhan Khinteel
Date
2015Supervisor
Prof. Vivian Sunderland
Dr Victor Chuang
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School of Pharmacy
Remarks
This thesis is under permanent embargo
Collection
Abstract
Oxytocin is important treatment in labour. This study investigated the degradation kinetics of oxytocin as a function of temperature, pH and other parameters and investigated the influence of formulation additives. Also investigated the storage of some of oxytocin injection stored in Vietnam. Oxytocin was most stable at pH 3.5 but highly affected by temperature. Improper storage can lead to premature expiry when the injection is not refrigerated.
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