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    Stabilisation of oxytocin in aqueous injection solutions

    Access Status
    Fulltext not available
    Authors
    Al Zayadi, Ahmad Farhan Khinteel
    Date
    2015
    Supervisor
    Prof. Vivian Sunderland
    Dr Victor Chuang
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Pharmacy
    Remarks

    This thesis is under permanent embargo

    URI
    http://hdl.handle.net/20.500.11937/1911
    Collection
    • Curtin Theses
    Abstract

    Oxytocin is important treatment in labour. This study investigated the degradation kinetics of oxytocin as a function of temperature, pH and other parameters and investigated the influence of formulation additives. Also investigated the storage of some of oxytocin injection stored in Vietnam. Oxytocin was most stable at pH 3.5 but highly affected by temperature. Improper storage can lead to premature expiry when the injection is not refrigerated.

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