Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets
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Mesothelioma is a cancer that occurs in the elderly. Dendritic cells (DC) play a key role in generating immune responses. This thesis examined DCs in elderly mesothelioma patients and reports that numerical and functional defects due to aging were significantly amplified in mesothelioma patients. Whilst CD40 stimulation recued the function of healthy elderly DCs it offered little benefit to mesothelioma DCs. Surgery improved mesothelioma DC function implying a window of opportunity for use of immunotherapies.
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Familial aggregation of malignant mesothelioma in former workers and residents of Wittenoom, Western AustraliaDe Klerk, N.; Alfonso, Helman; Olsen, N.; Reid, Alison; Sleith, J.; Palmer, L.; Berry, G.; Musk, A. (2013)Clustering of cases of malignant mesothelioma within families has often been observed, but disentangling genetic and exposure effects has not been done. Former workers and residents exposed to crocidolite at Wittenoom, ...
Malignant mesotheliomas in former miners and millers of crocidolite at Wittenoom (Western Australia) after more than 50 years follow-upBerry, G.; Reid, Alison; Aboagye-Sarfo, P.; De Klerk, N.; Olsen, N.; Merler, E.; Franklin, P.; Musk, A. (2012)Background: To report the number of malignant pleural and peritoneal mesotheliomas that have occurred in former Wittenoom crocidolite workers to the end of 2008, to compare this with earlier predictions, and to relate the ...
Predicted mortality from malignant mesothelioma among women exposed to blue asbestos at Wittenoom, Western AustraliaReid, Alison; Berry, G.; Heyworth, J.; De Klerk, N.; Musk, A. (2009)Introduction: Nearly 3000 women and girls were documented to have lived at the blue asbestos mining and milling town of Wittenoom in Western Australia between 1943 and 1992. Eight per cent of deaths among these women to ...