Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets
Access Status
Open access
Authors
Cornwall, Scott M.J.
Date
2015Supervisor
Dr Delia Nelson
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School of Biomedical Science
Collection
Abstract
Mesothelioma is a cancer that occurs in the elderly. Dendritic cells (DC) play a key role in generating immune responses. This thesis examined DCs in elderly mesothelioma patients and reports that numerical and functional defects due to aging were significantly amplified in mesothelioma patients. Whilst CD40 stimulation recued the function of healthy elderly DCs it offered little benefit to mesothelioma DCs. Surgery improved mesothelioma DC function implying a window of opportunity for use of immunotherapies.
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