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    Studies on the Effect of Aging and Mesothelioma on Dendritic Cell Subsets

    238411_Cornwall 2015.pdf (4.110Mb)
    Access Status
    Open access
    Authors
    Cornwall, Scott M.J.
    Date
    2015
    Supervisor
    Dr Delia Nelson
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    School
    School of Biomedical Science
    URI
    http://hdl.handle.net/20.500.11937/2236
    Collection
    • Curtin Theses
    Abstract

    Mesothelioma is a cancer that occurs in the elderly. Dendritic cells (DC) play a key role in generating immune responses. This thesis examined DCs in elderly mesothelioma patients and reports that numerical and functional defects due to aging were significantly amplified in mesothelioma patients. Whilst CD40 stimulation recued the function of healthy elderly DCs it offered little benefit to mesothelioma DCs. Surgery improved mesothelioma DC function implying a window of opportunity for use of immunotherapies.

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