Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis
Access Status
Open access
Authors
Köhn, Julia
Date
2016Supervisor
Dr Nina Tirnitz-Parker
Prof. John Olynyk
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Science
School
School of Biomedical Sciences
Collection
Abstract
The studies in this thesis aimed to characterise liver progenitor cells and their microenvironment during chronic liver injury conditions. A comprehensive comparison of the two common murine chronic liver disease models, CDE versus TAA, was performed. Parameters such as hepatocyte health, inflammation, fibrosis and the LPC response were investigated during stages of injury induction, establishment, maintenance, progression and carcinogenesis. Furthermore, the relationship between LPCs and HCC development in humans was investigated in a retrospective study.
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