Effect of dietary fats and metabolic determinants on chylomicron metabolism
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Atherosclerosis is initiated by the retention of remnant lipoproteins in the arterial subendothelial space. Indeed results from animal and human studies have demonstrated the presence of chylomicron remnants in atherosclerotic lesions. The dietary fatty acid composition has been recognised to modulate postprandial chylomicron response. This thesis explores the interactive effects of dietary fatty acid composition and physiological determinants on postprandial chylomicron response, specifically the pro-atherogenic remnant lipoprotein fraction.
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Consumption of low doses of fat prevents the postprandial rise in chylomicron particle concentration and remnant accumulation in healthy normolipidaemic malesJames, Anthony; Mamo, John (2012)Chylomicron particles are continually synthesised and secreted from the intestine even in the absence of ingested fat. It is possible that following consumption of low doses of fat the basal level of chylomicron secretion ...
Dietary fat and physiological determinants of plasma chylomicron remnant homoeostasis in normolipidaemic subjects: insight into atherogenic risk.Irawati, D.; Mamo, J.; Slivkoff-Clark, K.; Soares, M.; James, Tony (2017)TAG depleted remnants of postprandial chylomicrons are a risk factor for atherosclerosis. Recent studies have demonstrated that in the fasted state, the majority of chylomicrons are small enough for transcytosis to arterial ...
Plasma triglyceride and high density lipoprotein cholesterol are poor surrogate markers of pro-atherogenic chylomicron remnant homeostasis in subjects with the metabolic syndromeIrawati, D.; Mamo, John; Dhaliwal, S.; Soares, Mario; Slivkoff-Clark, K.; James, A. (2016)Background: Subjects with metabolic syndrome (MetS) exhibit impaired lipoprotein metabolism and have an increased risk of cardiovascular disease. Although the risk is attributed primarily to the risk associated with ...