Effect of dietary fats and metabolic determinants on chylomicron metabolism
Access Status
Open access
Authors
Date
2016Supervisor
Dr Tony James
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
Public Health
Collection
Abstract
Atherosclerosis is initiated by the retention of remnant lipoproteins in the arterial subendothelial space. Indeed results from animal and human studies have demonstrated the presence of chylomicron remnants in atherosclerotic lesions. The dietary fatty acid composition has been recognised to modulate postprandial chylomicron response. This thesis explores the interactive effects of dietary fatty acid composition and physiological determinants on postprandial chylomicron response, specifically the pro-atherogenic remnant lipoprotein fraction.
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Irawati, D.; Mamo, J.; Slivkoff-Clark, K.; Soares, M.; James, Tony (2017)TAG depleted remnants of postprandial chylomicrons are a risk factor for atherosclerosis. Recent studies have demonstrated that in the fasted state, the majority of chylomicrons are small enough for transcytosis to arterial ...
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James, Anthony; Mamo, John (2012)Chylomicron particles are continually synthesised and secreted from the intestine even in the absence of ingested fat. It is possible that following consumption of low doses of fat the basal level of chylomicron secretion ...
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Irawati, D.; Mamo, John; Dhaliwal, S.; Soares, Mario; Slivkoff-Clark, K.; James, A. (2016)Background: Subjects with metabolic syndrome (MetS) exhibit impaired lipoprotein metabolism and have an increased risk of cardiovascular disease. Although the risk is attributed primarily to the risk associated with ...