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dc.contributor.authorRichards, Alexander S.K.
dc.contributor.supervisorDr Simon Foxen_US
dc.date.accessioned2017-10-04T07:18:56Z
dc.date.available2017-10-04T07:18:56Z
dc.date.issued2016
dc.identifier.urihttp://hdl.handle.net/20.500.11937/56433
dc.description.abstract

The aims of this thesis were to characterise the Wnt signalling system and its pharmacological modulation in mesothelioma derived cell lines using monolayer and three dimensional culture models. Investigations into the effects upon expression of Wnt signal components were performed by inhibiting tankyrase enzymes with the compound XAV939 and histone deacetylase enzymes with suberoylanilide hydroxamic acid. Measurement of effects was carried out using functional assays and RNA sequencing for differential gene expression.

en_US
dc.publisherCurtin Universityen_US
dc.titleWnt Signalling in Malignant Mesotheliomaen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Pharmacyen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealthen_US


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