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    Pigment Epithelium-derived Factor and Insulin Crosstalk in Skeletal Muscle Biology

    Carnagarin R 2017.pdf (8.284Mb)
    Access Status
    Open access
    Authors
    Carnagarin, Revathy
    Date
    2017
    Supervisor
    Prof. Crispin Dass
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Pharmacy
    URI
    http://hdl.handle.net/20.500.11937/59666
    Collection
    • Curtin Theses
    Abstract

    PEDF is an important regulator of skeletal muscle metabolism, in particular the insulin–dependent metabolic processes. The attenuation of PEDF signalling is an effective approach to achieve better control over the insulin resistance of metabolic disorders and the PEDF-insulin antagonistic cross talk involved in the modulation of skeletal muscle biology could be an effective strategy to achieve controlled bone formation counteracting the PEDF-induced heterotrophic ossification.

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    • PEDF attenuates insulin-dependent molecular pathways of glucose homeostasis in skeletal myocytes
      Carnagarin, R.; Dharmarajan, Arunasalam; Dass, Crispin (2015)
      Pigment epithelium-derived factor (PEDF) is an anti-angiogenic serpin associated with insulin resistance in metabolic disorders such as diabetes, metabolic syndrome, obesity and polycystic ovarian syndrome. While the ...
    • Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse islets
      Chen, Y.; Carlessi, Rodrigo; Walz, N.; Cruzat, Vinicius; Keane, Kevin; John, A.; Jiang, F.; Carnagarin, R.; Dass, C.; Newsholme, Philip (2016)
      Pigment epithelium-derived factor (PEDF) is a multifunctional glycoprotein, associated with lipid catabolism and insulin resistance. In the present study, PEDF increased chronic and acute insulin secretion in a clonal rat ...
    • PEDF-induced alteration of metabolism leading to insulin resistance
      Carnagarin, Revathy; Dharmarajan, Arunasalam; Dass, Crispin (2015)
      Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in ...
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