Pigment Epithelium-derived Factor and Insulin Crosstalk in Skeletal Muscle Biology
Access Status
Open access
Authors
Carnagarin, Revathy
Date
2017Supervisor
Prof. Crispin Dass
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy
Collection
Abstract
PEDF is an important regulator of skeletal muscle metabolism, in particular the insulin–dependent metabolic processes. The attenuation of PEDF signalling is an effective approach to achieve better control over the insulin resistance of metabolic disorders and the PEDF-insulin antagonistic cross talk involved in the modulation of skeletal muscle biology could be an effective strategy to achieve controlled bone formation counteracting the PEDF-induced heterotrophic ossification.
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Chen, Y.; Carlessi, Rodrigo; Walz, N.; Cruzat, Vinicius; Keane, Kevin; John, A.; Jiang, F.; Carnagarin, R.; Dass, C.; Newsholme, Philip (2016)Pigment epithelium-derived factor (PEDF) is a multifunctional glycoprotein, associated with lipid catabolism and insulin resistance. In the present study, PEDF increased chronic and acute insulin secretion in a clonal rat ...
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