Pigment Epithelium-derived Factor and Insulin Crosstalk in Skeletal Muscle Biology
Prof. Crispin Dass
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School of Pharmacy
PEDF is an important regulator of skeletal muscle metabolism, in particular the insulin–dependent metabolic processes. The attenuation of PEDF signalling is an effective approach to achieve better control over the insulin resistance of metabolic disorders and the PEDF-insulin antagonistic cross talk involved in the modulation of skeletal muscle biology could be an effective strategy to achieve controlled bone formation counteracting the PEDF-induced heterotrophic ossification.
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Carnagarin, R.; Dharmarajan, Arunasalam; Dass, Crispin (2015)Pigment epithelium-derived factor (PEDF) is an anti-angiogenic serpin associated with insulin resistance in metabolic disorders such as diabetes, metabolic syndrome, obesity and polycystic ovarian syndrome. While the ...
Pigment epithelium-derived factor (PEDF) regulates metabolism and insulin secretion from a clonal rat pancreatic beta cell line BRIN-BD11 and mouse isletsChen, Y.; Carlessi, Rodrigo; Walz, N.; Cruzat, Vinicius; Keane, Kevin; John, A.; Jiang, F.; Carnagarin, R.; Dass, C.; Newsholme, Philip (2016)Pigment epithelium-derived factor (PEDF) is a multifunctional glycoprotein, associated with lipid catabolism and insulin resistance. In the present study, PEDF increased chronic and acute insulin secretion in a clonal rat ...
Carnagarin, Revathy; Dharmarajan, Arunasalam; Dass, Crispin (2015)Pigment epithelium-derived factor (PEDF) is an anti-angiogenic, immunomodulatory, and neurotrophic serine protease inhibitor protein. PEDF is evolving as a novel metabolic regulatory protein that plays a causal role in ...