Crystallisation of Calcium Oxalate Solids in the Presence of Tetrazoles
Access Status
Open access
Authors
Date
2017Supervisor
Dr Franca Jones
Assoc. Prof. Max Massi
Type
Thesis
Award
PhD
Metadata
Show full item recordFaculty
Science and Engineering
School
Chemistry
Collection
Abstract
A series of tetrazoles-containing molecules were investigated for their impact on calcium oxalate monohydrate (COM) crystallisation for the first time. COM is the main constituent of kidney stones, a common pathological mineral in humans. The tetrazole series was found to inhibit the morphology, crystal growth and nucleation of COM directly through selective adsorption or by a complexation mechanism, to varying degrees. Structural trends and which of the tetrazole molecules as crystal growth modifiers were confirmed.
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