Diagnosing Fetal Aneuploidy in Australia: The Impact of Prenatal Screening and the Integration of New Technology

Maxwell, Susannah

Maxwell S 2017.pdf (6.105Mb)

Access Status

Open access

Authors

Maxwell, Susannah

Date

2017

Supervisor

Prof. Peter O'Leary

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

Public Health

URI

http://hdl.handle.net/20.500.11937/66690

Collection

Curtin Theses

Abstract

This thesis explores the historical uptake, impact, performance and outcomes of prenatal screening for fetal aneuploidy in Western Australia. New models were developed to evaluate the economic and clinical impact of new non-invasive cell free DNA (NIPT cfDNA) testing. NIPT can improve the detection of fetal Down syndrome and reduce invasive diagnostic testing and procedure related loss. These studies provide evidence to support the translation of NIPT into national public health policy.