Targeted topical delivery of peptides and small molecules to the skin

Abstract

This PhD project demonstrates the importance of minimally invasive techniques such as microneedles and non-invasive techniques such as cell penetrating peptides and magnetophoresis for enhanced transdermal delivery. Skin penetration strategies studied, showed enhancement in delivery of peptides and small molecules ranging from a few percent to several fold and have tremendous potential for clinical therapy upon demonstration of safety and efficacy.