Evaluation of the stability of exenatide in aqueous solutions

dc.contributor.author	Al Assadi, Ali
dc.contributor.supervisor	Dr Hani Al-Salami
dc.contributor.supervisor	Prof. Bruce Sunderland
dc.date.accessioned	2017-01-30T09:53:13Z
dc.date.available	2017-01-30T09:53:13Z
dc.date.created	2015-10-30T05:17:15Z
dc.date.issued	2015
dc.identifier.uri	http://hdl.handle.net/20.500.11937/744
dc.description.abstract	Exenatide is an Incretin Mimetic which stimulates insulin secretion, suppresses glucagon secretion and inhibits gastric emptying. This study aimed to evaluate the stability of exenatide in aqueous solutions. Exenatide was most stable at pH 6 and the reaction rate was highly temperature dependent. Exenatide degradation followed first order kinetics under all conditions employed. Future studies should aim at investigating a more stable exenatide formulation and a more convenient route of administration.
dc.language	en
dc.publisher	Curtin University
dc.title	Evaluation of the stability of exenatide in aqueous solutions
dc.type	Thesis
dcterms.educationLevel	MPhil
curtin.department	School of Pharmacy
curtin.accessStatus	Open access