A Novel Radiofluorination Method for the Design of Rhenium(I) PET-Optical Hybrid Nuclear Medicines

Klenner, Mitchell Ashley

Klenner M 2019.pdf (14.24Mb)

Access Status

Open access

Authors

Klenner, Mitchell Ashley

Date

2019

Supervisor

Max Massi

Type

Thesis

Award

PhD

Metadata

Show full item record

Faculty

Science and Engineering

School

School of Molecular and Life Sciences

URI

http://hdl.handle.net/20.500.11937/77107

Collection

Curtin Theses

Abstract

Novel fluorine-18 labelled luminescent rhenium tricarbonyl complexes were synthesised to test their utility as agents for position emission tomography (PET) and optical hybrid imaging. These experiments lead to the discovery of a rhenium complexation-dissociation method, which produced never-before-seen radiotracers in substantial radiochemical yields that were unable to be radiosynthesised by traditional means. This method was further applied to the successful production of the Alzheimer’s disease PET imaging nuclear medicine, [18F]CABS13, and new analogues thereof.