Investigations into the Molecular, Isotopic and Genomic Mechanisms behind Human Gallstone Disease

Abstract

This thesis investigates the gallstones of 16 patients of diverse backgrounds and provides novel insights into the bacterial and physico-chemical processes that may lead to gallstone disease pathogenesis. It provides a more targeted framework for future research into this area, whilst simultaneously broadening its scope by applying hitherto untried interdisciplinary techniques to medical settings.