Investigating the Relationship Between Statins and Bacterial Skin Infections
Ko, Hean Teik Humphrey
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School of Pharmacy and Biomedical Sciences
Statins are extensively prescribed medicines to reduce cholesterol for cardioprotection, but they also exhibit antimicrobial and pleiotropic effects, which plausibly reduces both skin infection risks and antimicrobial resistance. Adopting a bench-to-bedside framework, the results of laboratory experiments (identifying suitable statins as topical antibiotics and postulating a mechanism of antibacterial action) and clinical evidence (via prescription sequence symmetry analysis and a retrospective case-control study) were reconciled to determine if prior statin use translated into beneficial outcomes.
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Kurniawan, Dede Indra (2007)Background. Muscle cramps are one of the adverse affects suffered by hypercholesterolemia patients who are treated with statins. Besides reducing cholesterol levels, statins also reduce coenzyme Q10 (CoQ10) blood levels. ...
Ko, H.; Lareu, Ricky R.; Dix, B.; Hughes, J. (2017)© 2017 Ko et al. Introduction. The repurposing of non-antibiotic drugs as adjuvant antibiotics may help break antimicrobial resistance (AMR). Statins are commonly prescribed worldwide to lower cholesterol. They also possess ...
Allen, S.; Mamotte, Cyril (2017)Statins are widely used to prevent major cardiovascular events by lowering serum cholesterol. There is evidence that statins have pleiotropic effects-that is, cholesterol-independent effects-that may also confer protection ...