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    Investigating the Relationship Between Statins and Bacterial Skin Infections

    Ko H 2019.pdf (12.84Mb)
    Access Status
    Open access
    Authors
    Ko, Hean Teik Humphrey
    Date
    2019
    Supervisor
    Ricky Lareu
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/77546
    Collection
    • Curtin Theses
    Abstract

    Statins are extensively prescribed medicines to reduce cholesterol for cardioprotection, but they also exhibit antimicrobial and pleiotropic effects, which plausibly reduces both skin infection risks and antimicrobial resistance. Adopting a bench-to-bedside framework, the results of laboratory experiments (identifying suitable statins as topical antibiotics and postulating a mechanism of antibacterial action) and clinical evidence (via prescription sequence symmetry analysis and a retrospective case-control study) were reconciled to determine if prior statin use translated into beneficial outcomes.

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