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dc.contributor.authorAdamska, Aleksandra
dc.contributor.supervisorMarco Falascaen_US
dc.date.accessioned2020-01-07T02:19:18Z
dc.date.available2020-01-07T02:19:18Z
dc.date.issued2019en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11937/77548
dc.description.abstract

Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease with high mortality rates and lacking effective therapeutic approach. Therefore, it is pivotal to develop novel treatments to improve the grim prognosis of patients. In my PhD project, I demonstrated the existence of an ABCC3-LPI-GPR55 loop in PDAC which activation boosts PDAC progression. Importantly, the pharmacological potential of this loop was demonstrated both in vitro and in vivo PDAC models paving a way to clinical trials.

en_US
dc.publisherCurtin Universityen_US
dc.titleABC transporters and G protein-coupled receptors: perspectives for novel anti-cancer drugsen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentSchool of Pharmacy and Biomedical Sciencesen_US
curtin.accessStatusOpen accessen_US
curtin.facultyHealth Sciencesen_US


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