The role of G protein-coupled receptor 35 in pancreatic cancer

Kim, Minkyoung

Kim M 2020.pdf (17.48Mb)

Access Status

Open access

Authors

Kim, Minkyoung

Date

2020

Supervisor

Marco Falasca

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

Curtin Medical School

URI

http://hdl.handle.net/20.500.11937/84527

Collection

Curtin Theses

Abstract

This PhD thesis discusses the novel therapeutic target of PDAC, which is GPR35. For the first time, we have characterized its diverse roles controlling apoptosis, autophagy, cell cycle arrests, migration and invasion in PDAC cells. In addition, this work provides its related signalling pathways which are AKT and HIF-1. Our investigation of GPR35 in PDAC has contributed to suggest a new therapeutic strategy to cure pancreatic cancer patients.