Epigenetic age estimation of cetaceans
MetadataShow full item record
Age is an important biological parameter which can be used to guide conservation. It is difficult to assess in wild populations, however, and especially in many cetacean species. Epigenetic analyses now offer an alternative for age estimation. In this thesis, I identified the benefits and considerations of epigenetic age estimators for cetaceans, developed a novel high-throughput sequencing workflow for homology-based epigenetic analyses, and successfully built age estimation assays for both sperm and Southern right whales.
Showing items related by title, author, creator and subject.
Epigenetic age acceleration in adolescence associates with BMI, inflammation and risk score for middle age cardiovascular diseaseHuang, R.; Lillycrop, K.; Beilin, L.; Godfrey, K.; Anderson, D.; Mori, T.; Rauschert, S.; Craig, J.; Oddy, W.; Ayonrinde, O.; Pennell, C.; Holbrook, J.; Melton, Phillip (2019)BACKGROUND: 'Accelerated ageing', assessed by adult DNA methylation predicts cardiovascular disease (CVD). Adolescent accelerated aging might predict CVD earlier. We investigated whether epigenetic age acceleration (assessed ...
Nustad, H.; Almeida, M.; Canty, A.; Leblanc, M.; Page, C.; Melton, Phillip (2018)© 2018 The Author(s). Background: Longitudinal data and repeated measurements in epigenome-wide association studies (EWAS) provide a rich resource for understanding epigenetics. We summarize 7 analytical approaches to the ...
Pedersen, J.; Valen, E.; Velazquez, A.; Parker, B.; Rasmussen, M.; Lindgreen, S.; Lilje, B.; Tobin, D.; Kelly, T.; Vang, S.; Andersson, R.; Jones, P.; Hoover, C.; Tikhonov, A.; Prokhortchouk, E.; Rubin, E.; Sandelin, A.; Gilbert, Thomas; Krogh, A.; Willerslev, E.; Orlando, L. (2014)Epigenetic information is available from contemporary organisms, but is difficult to track back in evolutionary time. Here, we show that genome-wide epigenetic information can be gathered directly from next generation ...