Design, synthesis and application of luminescent metal tetrazolato complexes in optical imaging
Access Status
Open access
Authors
Date
2014Supervisor
Dr Max Massi
Prof. Mark Ogden
Assoc. Prof. Paul Rigby
Type
Thesis
Award
PhD
Metadata
Show full item recordSchool
School of Science and Engineering
Remarks
The full version of this thesis is embargoed until 21-05-2020
Collection
Abstract
Fundamental investigation into a series of Re(I) tetrazolato complexes as optical imaging agents provided insight into how structural modifications influence their chemical, photophysical and biological properties. Modulation of the complexes through protonation and methylation of the tetrazolato ligand led to improved photophysical performance. Functionalisation at the diimine ligand revealed photophysical output is not appreciably altered. Live cell imaging with the Re(I) complexes showed HeLa cell uptake with perinuclear localisation.
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