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    MCAM in Melanoma Metastasis: The Role of Putative Endocytosis Motifs

    Harfield J 2021.pdf (14.74Mb)
    Access Status
    Open access
    Authors
    Harfield, Jake
    Date
    2021
    Supervisor
    Danielle Dye
    Deirdre Coombe
    Type
    Thesis
    Award
    MRes
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    School of Pharmacy and Biomedical Sciences
    URI
    http://hdl.handle.net/20.500.11937/85747
    Collection
    • Curtin Theses
    Abstract

    Melanoma cell adhesion molecule (MCAM) is a marker of melanoma metastasis and contributes to melanoma progression but how MCAM is sorted and recycled through the cell is unknown. Two putative endocytosis motifs have been identified in the intracellular domain of MCAM. The generation of wild-type and mutant MCAM expressing Colo239F cells was explored in this thesis to determine the role of these endocytosis motifs in melanoma metastasis.

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