MCAM in Melanoma Metastasis: The Role of Putative Endocytosis Motifs
Access Status
Fulltext not available
Embargo Lift Date
2023-09-28
Date
2021Supervisor
Danielle Dye
Deirdre Coombe
Type
Thesis
Award
MRes
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
Melanoma cell adhesion molecule (MCAM) is a marker of melanoma metastasis and contributes to melanoma progression but how MCAM is sorted and recycled through the cell is unknown. Two putative endocytosis motifs have been identified in the intracellular domain of MCAM. The generation of wild-type and mutant MCAM expressing Colo239F cells was explored in this thesis to determine the role of these endocytosis motifs in melanoma metastasis.
Related items
Showing items related by title, author, creator and subject.
-
Stewart, Louise; Holman, C. D'Arcy; Finn, Judith; Preen, David; Hart, Roger (2013)A link between reproductive hormones and melanoma has long been suspected, and has been examined for numerous hormonal exposures, but the association between in-vitro fertilization (IVF) and melanoma has not been studied ...
-
Dye, Danielle; Medic, S.; Ziman, M.; Coombe, Deirdre (2013)The majority of patients diagnosed with melanoma present with thin lesions and generally these patients have a good prognosis. However, 5% of patients with early melanoma (<1 mm thick) will have recurrence and die within ...
-
Cadby, G.; Ward, S.; Cole, J.; Moses, Eric; Millward, M.; Palmer, L. (2014)Background: Breslow thickness is the most important predictor of survival in localized malignant melanoma. A number of melanoma risk factors have been shown to be associated with Breslow thickness; however, the role of ...