Evaluation of Chitosan-Based Nanoparticles in Oral Delivery of Insulin
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Diabetes mellitus is a chronic metabolic disorder. To improve patient compliance and alleviate the unwanted side effects that are associated with insulin injections, the project aimed to evaluate the potential of nanoparticles in oral delivery of insulin. The developed nanoparticles maintained the bioactivity of the entrapped insulin, and demonstrated a balance in mucoadhesiveness strength and muco-penetrating capacity. The nanoparticles could preserve the physicochemical properties upon storage, and induce glucose uptake in skeletal muscle cells.
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Wong, C.; Al-Salami, Hani; Dass, Crispin (2017)© 2017 Elsevier B.V. Nanoparticles have demonstrated significant advancements in potential oral delivery of insulin. In this publication, we review the current status of polymeric, inorganic and solid-lipid nanoparticles ...
Gedawy, A.; Martinez, Jorge; Al-Salami, Hani; Dass, Crispin (2017)Objectives: The chronic and progressive nature of diabetes is usually associated with micro- and macrovascular complications where failure of pancreatic ß-cell function and a general condition of hyperglycaemia is created. ...
Microparticles, microcapsules and microspheres: A review of recent developments and prospects for oral delivery of insulinWong, C.; Al-Salami, Hani; Dass, Crispin (2018)© 2017 Elsevier B.V. Diabetes mellitus is a chronic metabolic health disease affecting the homeostasis of blood sugar levels. However, subcutaneous injection of insulin can lead to patient non-compliance, discomfort, pain ...