Investigating the structure and binding mechanism of QseM,
a novel dual-target protein-inhibitor

Hall, Drew Anthony

Hall DA 2021.pdf (9.170Mb)

Access Status

Open access

Authors

Hall, Drew Anthony

Date

2021

Supervisor

Joshua Ramsay

Carl Mousley

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

Curtin Medical School

URI

http://hdl.handle.net/20.500.11937/87895

Collection

Curtin Theses

Abstract

This thesis details the structural characterisation of a novel protein, QseM, through the use of X-ray crystallography and nuclear magnetic resonance. QseM contains the uncharacterised DUF2285 domain, which, through this work, has been revealed to be a novel helix-turn-helix motif.

Investigating the structure and binding mechanism of QseM, a novel dual-target protein-inhibitor