Does PITP dependant PtdIns-4-P production promote encystation in Giardia duodenalis?
Access Status
Open access
Authors
Davis, Aleesha Jayne
Date
2020Supervisor
Carl Mousley
Rob Steuart
Type
Thesis
Award
MRes
Metadata
Show full item recordFaculty
Health Sciences
School
School of Pharmacy and Biomedical Sciences
Collection
Abstract
Giardia duodenalis is a parasite responsible for intestinal infection worldwide. This study, investigates the developmental process responsible for infection, termed of encystation. Here we investigated a protein which highly-conserved across eukaryotes, yet uncharacterized in G. duodenalis, Phosphatidylinositol Transfer Protein (PITP). We have developed a system to determine the binding activity of this protein to determine its function in the lifecycle of G. duodenalis which may aid in the identification of a novel pharmaceutical target.