Developing Multimodal Spectroscopic Imaging Techniques to Study Metal Dyshomeostasis and Altered Brain Biochemistry During Ageing

Abstract

Cognitive decline and neurodegenerative diseases such as Alzheimer’s disease, pose significant concerns for the ageing population. Increased understanding of the biochemical processes that occur during ageing, may help to reveal pathways for prevention or treatment. There has been interest in the potential role that metal dis-homeostasis plays during ageing and cognitive decline, so this thesis has focussed on developing and applying spectroscopic methods to study metal dis-homeostasis and concomitant biochemical changes during ageing.