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dc.contributor.authorMalajczuk, Chris
dc.contributor.supervisorRicardo Manceraen_US
dc.date.accessioned2023-02-28T03:38:00Z
dc.date.available2023-02-28T03:38:00Z
dc.date.issued2022en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11937/90684
dc.description.abstract

High-density lipoproteins (HDLs) are small, protein-lipid particles that transport cholesterol in the blood. HDLs have been proposed to protect against Alzheimer’s Disease via the specific binding and clearance of beta-amyloid, a plaque-forming protein that can accumulate in the brain. This research aimed to develop and characterise realistic computational models of representative HDLs of different sizes and compositions, to identify the structural and functional differences between particles that inform their capacity to effectively bind beta-amyloid.

en_US
dc.publisherCurtin Universityen_US
dc.titleThe structure and dynamics of plasma high-density lipoproteins and their interactions with the beta-amyloid peptideen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentCurtin Medical Schoolen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US
curtin.contributor.orcidMalajczuk, Chris [0000-0002-8865-090X]en_US
dc.date.embargoEnd2025-02-24


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