Isolation and Synthesis of Anti-Inflammatory Compounds from Dodonaea Species

Abstract

In this thesis Dodonaea species were investigated for their bioactive natural products, focusing on their anti-inflammatory activity. Dodonaea adenophora (Kalgoorlie) yielded numerous clerodanes diterpenoids, of which one proved to be highly active as an anti-malarial and as an anti-cancer agent, with low toxicity. The structure of these clerodanes was modified to better resemble polyandric acid A, a known anti-inflammatory. Dodonaea boroniifolia (cult.) yielded two novel cembrane diterpenoids, whose bioactivity and chemistry were explored.