Development and evaluation of novel biodegradable nanoparticles for vaccine delivery

Abstract

The development and evaluation of a chitosan-dextran sulfate nanoparticulate vaccine delivery system, with incorporation of Immunoglobulin-A as an immunological adjuvant with M-cell targeting potential, are described in this thesis. This research project highlights the importance of nanoparticulate systems and novel adjuvants in the development of efficient and safe vaccines with an emphasis on defining a correlation between pharmaceutical formulation factors and in-vivo immunological responses.