The role of the HGF/c-MET signalling pathway in
cellular crosstalk during chronic liver injury

Pasic, Sara

Pasic S 2023 Public.pdf (25.10Mb)

Access Status

Open access

Authors

Pasic, Sara

Date

2023

Supervisor

Nina Tirnitz-Parker

Pieter Eichhorn

Borut Klopcic

Type

Thesis

Award

PhD

Metadata

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Faculty

Health Sciences

School

Curtin Medical School

URI

http://hdl.handle.net/20.500.11937/93361

Collection

Curtin Theses

Abstract

The HGF/c-MET signalling pathway is known to be antifibrotic in the liver. However, its influence on liver progenitor cell (LPC) and hepatic stellate cell (HSC) communication during chronic liver disease (CLD) is unknown. Here, CRISPR/Cas9 technology was utilised to create a c-MET knockout LPC line, which altered LPC biology and diminished the HSC-regulatory potential of LPCs. These findings suggest that HGF/c-MET signalling is important for maintaining LPC biology and regulating HSC behaviour in CLD.