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    Understanding the Relationship between Iron and Lipid Metabolism in Non-alcoholic Fatty Liver Disease

    Singh AK 2022 Public.pdf (4.565Mb)
    Access Status
    Open access
    Authors
    Singh, Abhishek Kumar
    Date
    2022
    Supervisor
    Ross Graham
    Cyril Mamotte
    Type
    Thesis
    Award
    PhD
    
    Metadata
    Show full item record
    Faculty
    Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/93623
    Collection
    • Curtin Theses
    Abstract

    This research shows that in the absence of steatosis short term iron exposure appears to improve mitochondrial function and decrease mitochondrial fatty acid breakdown. In contrast, in the presence of hepatic steatosis, iron increased peroxisomal fatty acid breakdown. Importantly, iron decreased the number of cholesterol crystals present in fatty liver. These results suggest iron loading in steatosis may act to reduce liver damage in non-alcoholic fatty liver disease.

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