Investigating therapeutic intervention strategies in pancreatic cancer

Abstract

Based on the published literature and the identified gaps, this study aimed to investigate the therapeutic intervention strategies in pancreatic cancer. Preclinical validation of cannabinoids in a relevant mouse model of pancreatic cancer was performed, and the therapy-associated changes in the gut microbiota/bile acid axis were assessed. Based on in vivo results, the biomarker potential of bile acids was evaluated in PC patients compared to healthy participants.