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dc.contributor.authorBelhoul-Fakir, Hanane
dc.contributor.supervisorShirley Jansenen_US
dc.contributor.supervisorJuliana Hamzahen_US
dc.date.accessioned2024-03-28T01:12:23Z
dc.date.available2024-03-28T01:12:23Z
dc.date.issued2024en_US
dc.identifier.urihttp://hdl.handle.net/20.500.11937/94619
dc.description.abstract

Atherosclerosis is initiated in the arterial intima following injury, while media is the least known in atherogenesis. This thesis examined changes to the media following micro-injuries in pig aortas and assessed human carotid plaques to detect atherogenesis in the media. This thesis presents evidence that atherogenesis can begin in the medial layer, potentially influencing plaque rupture mechanisms. Furthermore, this work supports TNFa-CSG as a promising anti-atherosclerotic drug, offering a unique lipid-clearing approach compared to current therapies.

en_US
dc.publisherCurtin Universityen_US
dc.titleImpact of Arterial Wall Injury on Atherosclerosis Initiation and Potential for Targeted Therapyen_US
dc.typeThesisen_US
dcterms.educationLevelPhDen_US
curtin.departmentCurtin Medical Schoolen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US
curtin.contributor.orcidBelhoul-Fakir, Hanane [0000-0002-8280-3717]en_US
dc.date.embargoEnd2026-03-06


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