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dc.contributor.authorPanting, Rhiannon
dc.contributor.supervisorLaurence Cheungen_US
dc.contributor.supervisorRishi Kotechaen_US

The tumour microenvironment has been shown to support cancer progression and regulate responsiveness to drug treatment. In leukaemia, chemoresistance is often facilitated by stromal cells of the bone marrow microenvironment. In this project, we established a co-culture drug screening pipeline and discovered that the stromal cells conferred anthracycline resistance to BCR-ABL1+ chronic myeloid leukaemia. We further investigated the mechanism of chemoresistance, paving the way to design the most effective therapeutic approach for these patients.

dc.publisherCurtin Universityen_US
dc.titleEstablishing a Bioluminescent Screening Platform to Identify Stromal-Mediated Chemoresistance in Leukaemiaen_US
curtin.departmentCurtin Medical Schoolen_US
curtin.accessStatusFulltext not availableen_US
curtin.facultyHealth Sciencesen_US
curtin.contributor.orcidPanting, Rhiannon [0000-0002-3146-6984]en_US

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