Progress Towards the Integration of Experimental and Computational Techniques to Better Understand the Delivered Dose of Aerosolised Medication

Abstract

A significant gap exists in our knowledge of how to deliver inhaled medicines effectively and safely to children and adolescents, and off-label respiratory drug use is common in hospitals. Inhaled medication delivery is difficult to study in situ and likely improved using computational methods. Here, computational fluid dynamics and experimental techniques were used to improve our understanding of inhaled medicines delivered off-label to children/adolescents and assess safety of unapproved therapeutic “e-cigarette” use by adolescents.