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    Bile acid-based bio micro/nanotechnologies; biocompatibility studies

    Kovacevic B 2024 Public.pdf (10.68Mb)
    Access Status
    Open access
    Authors
    Kovacevic, Božica
    Date
    2024
    Supervisor
    Hani Al-Salami
    Armin Mooranian
    Type
    Thesis
    Award
    PhD
    
    Metadata
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    Faculty
    Health Sciences
    School
    Curtin Medical School
    URI
    http://hdl.handle.net/20.500.11937/95648
    Collection
    • Curtin Theses
    Abstract

    Biocompatible hydrogels are versatile biomaterials utilized for micro/nano-encapsulation, injectable gels, and bioprinted scaffolds, facilitating drug and cell delivery. Bile acids, known permeation enhancers, self-assemble into micelles, augmenting drug absorption through membrane interactions. They enhance biomaterial durability and reduce inflammation, activating various receptors for immunomodulation. Incorporating bile acids into hydrogel matrices improves rheological properties and biocompatibility, with smart thermoresponsive nanogels exhibiting promise as inner ear drug delivery vehicles.

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